Possibilities of cryoglobulin synthesis inhibition in patients with chronic hepatitis C by the method of intradermal immunization with inactivated autoleukocytes, isolated from heparinized venous blood, have been presented in the article. Immunization was conducted in three groups of patients with chronic hepatitis C with mixed cryoglobulinemia. The first group comprised 28 patients, who followed antiviral therapy with pegylated interferon and ribavirin; the second – 12 patients with mild and asymptomatic course of chronic hepatitis C (detected accidentally). Besides, autoleukocyte immunization was performed to 8 patients with severe vasculitis and contraindications for interferon therapy. Autoleukocyte immunization causes decrease in cryoglobulin amount in all patients (100%); in the majority of them a significant reduction of clinical manifestations of cryoglobulinemia syndrome occurred. The degree of positive influence of autoleukocyte immunization on clinical manifestations of cryoglobulinemia syndrome had individual character and depended on the severity of vasculitis. The method is recommended for introduction into clinical practice.